The Department of Mathematics was established in 2019 according to Law 4610/07.05.2019, concerning the Synergies between Universities and Technological Educational Institutions (Government Gazette No. 4610/07.05.2019, issue 70).

The Department of Mathematics is located in Kastoria and is part of the Faculty of Sciences. It welcomed students for the first time in the academic year 2019-2020. The Department leads to a Bachelor's Degree in Mathematics (without specializations and directions) and according to the National Qualifications Framework is defined at Level 6 (equivalent to the Bachelor's Degree).

The academic character of the Department of Mathematics of the University of Western Macedonia focuses on the teaching of mathematics, the cultivation of mathematical thinking and the development of basic research in all classical areas of mathematics such as Algebra, Analysis, Numerical Analysis, Geometry, Statistics and Operations Research.

The mission of the Department of Mathematics is, among other things, to train mathematicians of high quality and scientific training, capable of working at all levels of education, as well as in a variety of other private and public professions. In addition, the Department prepares its graduates in the new areas of the science and profession of mathematics by keeping abreast of international developments. Also, to the extent possible, the mission of the Department of Mathematics is to play an active role in the local community.